Short-term fasting reshapes fat tissue

Intermittent fasting, which can effectively reduce obesity and improve the related metabolic syndrome has become an exciting research area in recent years. Adipose tissue is pivotal regulating metabolism determining occurrence of obesity. In current study, we aimed to investigate effects acute fasting (AF) on fat tissue. Mice were subjected AF for 36 h, receiving normal chow (low-fat diet [LFD]) or a high-fat (HFD), with free ad libitum access drinking water, those fed free-diet counterparts without serveding as controls. We found that obviously reshaped morphology (WAT) promoted beiging white adipose both LFD- HFD-fed mice. principally improved lipid metabolism, increased M2- polarization macrophages WAT Interestingly, dramatically upregulated Sirt5 expression levels succinylation, suggesting AF-induced beneficial might occur via regulation altered succinylation fatty tissues. Our study clearly showed remodeling function during AF; terms mechanism, by provide new insights into mechanism(s) underlying improvement energy restriction.